El discurso sobre la biología sintética y la innovación responsable : Observaciones desde una perspectiva histórica = Discourse about synthetic biology and responsible innovation : Notes from a historical perspective

El discurso sobre la biología sintética, altamente visionario y marcado por el enfoque de ‘investigación e innovación responsable’ (RRI) puede interpretarse como un terreno para confrontar perspectivas sobre el futuro de nuestras sociedades en su conjunto. En un momento en el que, con el final de la confrontación de sistemas entre capitalismo y socialismo, los debates sociales amplios sobre cuestiones políticas y socioeconómicas fundamentales se han vuelto infrecuentes, los discursos sobre las ciencias naturales y la tecnología parecen poder ayudar a tematizar estas cuestiones de manera indirecta. Esta función del discurso sobre la biología sintética puede clarificarse mediante una contextualización histórica del mismo, en la que se analizan aproximaciones anteriores sobre la relevancia social de la biología y sus aplicaciones tecnológicas

Quantum Technologies and Society: Towards a Different Spin

Due primarily to technological advances over the last decade, quantum research has become a key priority area for science and technology policy all over the world. With this manifesto, we wish to prevent quantum technology from running into fiascos of implementation at the interface of science and society. To this end, we identify key stumbling blocks and propose recommendations

Mutant mitochondrial elongation factor G1 and combined oxidative phosphorylation deficiency

Although most components of the mitochondrial translation apparatus are encoded by nuclear genes, all known molecular defects associated with impaired mitochondrial translation are due to mutations in mitochondrial DNA. We investigated two siblings with a severe defect in mitochondrial translation, reduced levels of oxidative phosphorylation complexes containing mitochondrial DNA (mtDNA)–encoded subunits, and progressive hepatoencephalopathy. We mapped the defective gene to a region on chromosome 3q containing elongation factor G1 (EFG1), which encodes a mitochondrial translation factor. Sequencing of EFG1 revealed a mutation affecting a conserved residue of the guanosine triphosphate (GTP)–binding domain. These results define a new class of gene defects underlying disorders of oxidative phosphorylation

A search for pulsars in subdwarf B binary systems and discovery of giant-pulse emitting PSR J0533-4524

Binary millisecond pulsars (MSPs) provide several opportunities for research of fundamental physics. However, finding them can be challenging. Several subdwarf B (sdB) binary systems with possible neutron star companions have been identified, allowing us to perform a targeted search for MSPs within these systems. Six sdBs with companions in the neutron star mass range, as determined from their optical light curves, were observed with the Green Bank and Westerbork radio telescopes. The data were searched for periodic signals as well as single pulses. No radio pulsations from sdB systems were detected, down to an average sensitivity limit of 0.11 mJy. We did, however, discover a pulsar in the field of sdB HE0532-4503. Follow-up observations with the Giant Metrewave Radio Telescope showed that this pulsar, J0533-4524, is not spatially coincident with the sdB system. The pulsar has a relatively low magnetic field but still emits giant pulses. We place an upper limit of three to the number of radio pulsars in the six sdB systems. The non-detections may be explained by a combination of the MSP beaming fraction, luminosity, and a recycling fraction <0.5. Alternatively, the assumption of co-rotation between the MSP and sdB may break down, which implies the systems are more edge-on than previously thought. This would shift the predicted companion masses into the white dwarf range. It would also explain the relative lack of edge-on sdB systems with massive companions.Comment: 12 pages, 8 figures. Accepted for publication in MNRA